张亚美，博士研究生，副研究员、硕士生导师
兼职情况：中国老年医学会数字诊疗专委会委员、中国医药质量管理协会医学检验质量管理专业委员会临床基因诊断质量管理学组委员、四川省医学会医学遗传学专业委员会委员、四川省医学会医学科研管理专业委员会委员、四川省医促会营养学专业委员会委员、四川省科学技术厅评审专家成员、四川中试专家库评审专家
最高学历毕业院校及专业：毕业于电子科技大学生物医学工程专业
所属学科：临床医学—医学遗传学
主要研究方向：医学教育、临床遗传分子诊断方向
主要教学及科研成果：
1. Zhang Y, Liu J, Su M, Wang X, Xie C. Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis. Stem Cell Res Ther. 2021 Feb 5;12(1):111. doi: 10.1186/s13287-020-02091-x. PMID: 33546766; PMCID: PMC7863295.
2. Zhang Y, Liu J, Wang X, Zhang J, Xie C. Extracellular vesicle-encapsulated microRNA-23a from dorsal root ganglia neurons binds to A20 and promotes inflammatory macrophage polarization following peripheral nerve injury. Aging (Albany NY). 2021 Feb 17;13(5):6752-6764. doi: 10.18632/aging.202532. Epub 2021 Feb 17. PMID: 33621204; PMCID: PMC7993670.
3. Zhang Y, Zhang Y, Zeng Q, Li C, Zhou H, Liu J, Shi Z, Ma L. IL-1β-Triggered Long Non-coding RNA CHRF Induces Non-Small Cell Lung Cancer by Modulating the microRNA-489/Myd88 Axis. J Cancer. 2022 May 16;13(8):2620-2630. doi: 10.7150/jca.63256. PMID: 35711847; PMCID: PMC9174862.
4. Liu J, Zhou Y, Xie C, Li C, Ma L, Zhang Y. Anti-Ferroptotic Effects of bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Loaded with Ferrostatin-1 in Cerebral ischemia-reperfusion Injury Associate with the GPX4/COX-2 Axis. Neurochem Res. 2023 Feb;48(2):502-518. doi: 10.1007/s11064-022-03770-2. Epub 2022 Nov 2. PMID: 36322371.
5. Liu XY, Li J, Zhang Y, Fan L, Xia Y, Wu Y, Chen J, Zhao X, Gao Q, Xu B, Nie C, Li Z, Tong A, Wang W, Cai J. Kidney microbiota dysbiosis contributes to the development of hypertension. Gut Microbes. 2022 Jan-Dec;14(1):2143220. doi: 10.1080/19490976.2022.2143220. PMID: 36369946; PMCID: PMC9662196.
6. Zhang Y, Liu J, Zhou Y, Zou Z, Xie C, Ma L. miR-18a-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates early brain injury following subarachnoid hemorrhage through blockade of the ENC1/p62 axis. Cell Tissue Res. 2023 Jun;392(3):671-687. doi: 10.1007/s00441-023-03754-w. Epub 2023 Feb 16. PMID: 36795153.
7. Li X, Qiao M, Zhou Y, Peng Y, Wen G, Xie C, Zhang Y. Modulating the RPS27A/PSMD12/NF-κB pathway to control immune response in mouse brain ischemia-reperfusion injury. Mol Med. 2024 Jul 22;30(1):106. doi: 10.1186/s10020-024-00870-3. PMID: 39039432.
8. Zhang Y, Liu J, Liu X, Zhou Y, Geng J, Shi Z, Ma L. Fecal Microbiota Transplantation-Mediated Ghrelin Restoration Improves Neurological Functions After Traumatic Brain Injury: Evidence from 16S rRNA Sequencing and In Vivo Studies. Mol Neurobiol. 2024 Feb;61(2):919-934. doi: 10.1007/s12035-023-03595-2. Epub 2023 Sep 5. PMID: 37668964.
9. Zhang Y, Hou H, Sui W, Liu Y, Zeng Q, Li Y, Li C, Zhou H, Zhang Y. Impact of ATP Synthase Subunit β on TLR Signaling Pathway in Promoting Airway Remodeling and Heterogeneity of Small Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease. J Innate Immun. J Innate Immun 2025;17:414–431. doi: 10.1159/000547329. Epub ahead of print. PMID: 40720940.
获奖或荣誉称号：
2023年度成都市医学科技奖，三等奖
2024年度四川省医学（青年）科技奖，三等奖
电子邮件：
yameizhang@126.com
